On the neuroscience of creativity

https://www.oldbookillustrations.com/wp-content/uploads/2018/02/attributes-art-illustration.jpgI was asked the following question on Quora recently:

What part of the brain is responsible for linear thinking? What part of the brain is responsible for creativity?

Thinking [1] [2] is very poorly understood, but broadly speaking in seems to involve the prefrontal cortex (PFC), with a special role for the dorsolateral PFC. Other important areas include the hippocampus and parietal cortex. Ultimately, thinking involves many brain regions, and cannot be localized to one place. Thinking is a distributed process that can incorporate many different parts of the brain. And the specific content of the thoughts will influence which brain areas are involved. If you are thinking about images, visual areas will be involved. If you are thinking about movement, motor areas will be involved.

In my opinion, the distinction between “linear” and “creative” thinking is somewhat vague. At this point, the most important thing to note is that the idea that the “left brain is rational/logical and the right brain is creative/artistic/emotional” is totally wrong [3] . Both hemispheres contribute to logic as well as creativity. Moreover, the use of logic can itself be a creative activity.

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Is thinking conscious or unconscious?

Sherlock Holmes smokes his pipe reclining on cushions and wearing a roomy overcoatThere are two ways to define thinking: each leads to a different answer to the question of whether thinking is conscious or not.

  1. Thinking as a subjective experience. If someone asks you what you are thinking about, you can introspect, and describe your thought process. You can also say that you weren’t really thinking at all.
  2. Thinking as the cause of ideas and thoughts. If you discover a thought, then you can infer that the process that led up to the thought was a form of thinking, even if there was no subjective experience associated with the process.

We can test our preference for definition 1 or definition 2 by considering an example.

Sherlock Holmes was a good chemist. When he found himself stuck while attempting to solve a mystery, he would sometimes distract himself by doing a chemistry experiment. At the end of such an experiment, he often found that a solution simply popped into his head.

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Is the ‘resolution’ of the human eye ‘infinite’?

No measurable physical quantity is ever infinite. In other words, only theoretical concepts can be definitively labeled as infinite. But that is perhaps an epistemological claim that is unnecessary here. So let’s dive into the nitty-gritty of how visual ‘resolution’ is actually measured. As we shall see, the number of light sensitive cells in the retina does not tell us what the ‘resolution’ of the visual system as a whole is. In some circumstances our visual ‘resolution’ exceeds that of the eye considered in isolation.

Visual acuity [1] is the sharpness with which we can distinguish patterns of light on the retina of the eye. This depends on the exact location of the light falling on the retina.

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Which is the most evolutionarily advanced part of the human brain?

This is a potentially controversial issue, since there is no consensus yet on the evolution of the brain, beyond a very coarse-grained chronology. Broadly speaking, neocortical areas are new, hence the term “neo-cortex”. But among cortical areas, there is still some disagreement about which areas emerged most recently in primates.

Based on what we know about development in the womb, along with structural findings, my labmates, who are neuroanatomists, suggest that the “eulaminate” areas — the ones that have sharply defined layers — may be the most recent, evolutionarily, compared to the “agranular” and “dysgranular” cortices, which have less sharply defined layers. These less sharply defined areas are also labeled as “limbic”.

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If serotonin deficiency isn’t the cause of depression, then why do SSRIs work?

Acetaminophen (a.k.a paracetamol) relieves some types of headache. But this does not mean that these headaches are caused by acetaminophen deficiency. The brain doesn’t even produce acetaminophen.

The point of this analogy is to make clear that a medicine can work even if it is not acting on the cause of the symptom. In many cases a medicine can work even when the cause of the symptom is completely unknown.

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Why is the brain so sensitive to early life experiences?

I was asked this question on Quora:

From an evolutionary standpoint, why would the early years of brain development be paramount in determining life-long neurological patterns, when those patterns can often be detrimental to long-term success in life?

Good question. We can restate it as follows:

Why would natural selection allow animals to be so sensitive to negative early experience?

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