If serotonin deficiency isn’t the cause of depression, then why do SSRIs work?

Acetaminophen (a.k.a paracetamol) relieves some types of headache. But this does not mean that these headaches are caused by acetaminophen deficiency. The brain doesn’t even produce acetaminophen.

The point of this analogy is to make clear that a medicine can work even if it is not acting on the cause of the symptom. In many cases a medicine can work even when the cause of the symptom is completely unknown.

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