Inhibition and Excitation: the Yin and Yang of the Brain

Do excitatory and inhibitory neurons make binary logic in the brain?

Not really. But it’s a good question because we learn a lot when we try to answer it.

First, we have to clarify what the words ‘excitatory’ and ‘inhibitory’ mean.

  • Excitation is the process by which a neuron’s membrane potential (or voltage) increases. If excitation is sufficient, a neuron will produce an action potential.
  • Inhibition is the process by y which a neuron’s membrane potential (or voltage) decreases. If a neuron is already firing, then if it receives enough inhibition, it will stop firing.

So the statement “If some neurons are excitatory meaning they will fire and some inhibitory meaning they won’t” is not quite right. All neurons, whether excitatory or inhibitory, can fire, but only if they receive adequate excitation. If an inhibitory neuron fires, it can reduce the voltage of other neurons, whether they are excitatory or inhibitory. Excitation is the accelerator for all neurons. Inhibition is the brake for all neurons.

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